منابع مشابه
PTEN, Longevity and Age-Related Diseases
Since the discovery of PTEN, this protein has been shown to be an effective suppressor of cancer and a contributor to longevity. This report will review, in depth, the associations between PTEN and other molecules, its mutations and regulations in order to present how PTEN can be used to increase longevity. This report will collect recent research of PTEN and use this to discuss PTEN's role in ...
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The role of cellular senescence (CS) in age-related diseases (ARDs) is a quickly emerging topic in aging research. Our comprehensive data mining revealed over 250 genes tightly associated with CS. Using systems biology tools, we found that CS is closely interconnected with aging, longevity and ARDs, either by sharing common genes and regulators or by protein-protein interactions and eventually ...
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In order to better understand the finitude of life it must be divided into its four components: aging, longevity determination, age-associated disease and death. Age changes result from the increasing rate of biomolecular disorder that, after reproductive maturation, exceeds repair and turnover capacity. These are stochastic or chance events governed by entropy or the tendency for concentrated ...
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Autophagy is a catabolic pathway in which the cell sequesters cytoplasmic material, including long-lived proteins, lipids and organelles, in specialized double-membrane vesicles, called autophagosomes. Subsequently, autophagosomes communicate with the lysosomal compartment and acquire acidic hydrolases for final cargo degradation. This process of partial self-eating secures the survival of euka...
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The Gadd45 proteins have been intensively studied, in view of their important role in key cellular processes. Indeed, the Gadd45 proteins stand at the crossroad of the cell fates by controlling the balance between cell (DNA) repair, eliminating (apoptosis) or preventing the expansion of potentially dangerous cells (cell cycle arrest, cellular senescence), and maintaining the stem cell pool. How...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2013
ISSN: 2227-9059
DOI: 10.3390/biomedicines1010017